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pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Warning/Observe. Drugs that raise delta-aminolevulinic acid synthetase may minimize hemin effect.Contraindicated (1)pentobarbital will decrease the level or effect of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Keep an eye on Intently (one)pentobarbi